潘艳雄　研究员----高分子物理与化学国家重点实验室

人才队伍

潘艳雄　研究员

文章来源：发布时间：2023-02-23

	潘艳雄　研究员
	博士生导师

	高分子化学与物理

	主楼430室

	电话：0431-85262595
	Email：yxpan@ciac.ac.cn
	网页：https://www.x-mol.com/groups/Jilab

教育和工作经历

2022-今中国科学院长春应化所研究员
2015-2022 美国北达科他州州立大学博士后
2014-2015 香港理工大学博士后
2009-2014 中国科学院长春应化所理学博士
2006-2009 中国科学院长春应化所研究实习员
2002-2006 东北师范大学理学学士

学术兼职

主要荣誉

研究兴趣

电子顺共振波谱技术，大分子（生物大分子）微观动力学，高性能高分子材料使役行为及其抗老化机理，功能性高分子材料

研究资助

研究领域和现状

1）大分子（生物大分子）微观动力学
通过原位监测大分子（生物大分子）在不同尺度下的动力学信息。建立大分子在不同状态下旋转相关时间（τc）与结构之间的关系，为从分子（链段）尺度来准确探究大分子的微观动力学变化及后续的使役行为提供有效的实验手段及理论支持。

2）高分子老化及抗老化机制
通过探明高分子材料在一系列不同服役条件下的结构演化、性能衰减规律及老化微观机理。提出老化和降解机理，预测材料的使用寿命，并为设计新型抗老化的高分子新材料奠定理论和技术基础。

主要代表性论文

30 Qiaobin Li, Zoe Armstrong, Austin MacRae, Angel Ugrinov, Li Feng, Bingcan Chen, Ying Huang, Hui Li*, Yanxiong Pan*, and Zhongyu Yang*, "Metal–Organic Materials (MOMs) Enhance Proteolytic Selectivity, Efficiency, and Reusability of Trypsin: A Time-Resolved Study on Proteolysis". ACS Appl. Mater. Interfaces 2023 (accepted)
29. Yanxiong Pan*, Qiaobin Li, Wei Liu, Zoe Armstrong, Austin E Macrae, Feng Li, Charles MaNeff, Pinjing Zhao, Hui Li*, Zhongyu Yang*. “Unveiling the Orientation and Dynamics of Enzymes in Unstructured Artificial Compartments of Metal-Organic Frameworks (MOFs)”. Nanoscale, 2023, 15, 2573-2577.
28. Drew Jordahl, Zoe Armstrong, Qiaobin Li, Runxiang Gao, Wei Liu, Kelley Johnson, William Brown, Allison Scheiwiller, Li Feng, Angel Ugrinov, Haiyan Mao, Bingcan Chen, Mohiuddin Quadir, Hui Li*, Yanxiong Pan*, Zhongyu Yang*. “Expanding the “Library” of Metal–Organic Frameworks for Enzyme Biomineralization”. ACS Appl. Mater. Interfaces 2022, 14, 51619.
27. Yanxiong Pan, Qiaobin Li, Hui Li, Mary Lenertz, Drew Jordahl, Zoe Armstrong, Bingcan Chen, Zhongyu Yang* “Maximizing the applicability of continuous wave (CW) Electron Paramagnetic Resonance (EPR): what more can we do after a century?”. Journal of Magnetic Resonance Open 10, 100060
26. Qiaobin Li, Yanxiong Pan*, Hui Li, Mary Lenertz, Kailyn Reed, Drew Jordahl, Taylor Bjerke, Angel Ugrinov, Bingcan Chen, Zhongyu Yang*. “Cascade/parallel biocatalysis via multi-enzyme encapsulation on Metal-Organic Materials for rapid and sustainable biomass degradation”. ACS Appl. Mater. Interfaces 2021, 13, 43085.
25. Yanxiong Pan#, Xiaoliang Wang, Hui Li, Junyu Ren, Yin Zhang, Drew Jordahl, Isabelle Schuster, Jasmin Farmakes, Heedeok Hong, Zhongyu Yang*, and Shengqian Ma*. “In situ monitoring the protein transfer into nanoscale channels” Cell Reports Physical Science 2021, 2, 100576.
24. Yanxiong Pan, Hui Li, Qiaobin Li, Mary Lenertz, Isabelle Schuster, Drew Jordahl, XiaoZhu, Bingcan Chen, Zhongyu Yang*. “Protocol for resolving enzyme orientation and dynamics in advanced porous materials via SDSL-EPR”. Star Protocol, 2021, 2, 100676.
23. Yanxiong Pan, Hui Li, Mary Lenertz, Yulun Han, Angel Ugrinov, Dmitri Kilin, Bingcan Chen, and Zhongyu Yang*. “One-pot “Green” Synthesis of “Green” Enzyme@Metal-Organic Materials (MOM) Biocomposites for Enzyme Biocatalysis”. Green Chem. 2021, 23, 4466.
22.Yanxiong Pan, Hui Li, Qiaobin Li, Mary Lenertz, Xiao Zhu, Bingcan Chen, and Zhongyu Yang*. “Site-directed spin labeling (SDSL) and Electron Paramagnetic Resonance (EPR) spectroscopy in heterogeneous biocatalysis: probing enzyme orientation and backbone dynamics under nanoscale confinement”. Chem Catalysis 2021, 1, 207.
21. Yanxiong Pan, Qiaobin Li, Hui Li, Jasmin Farmakes, Angel Ugrinov, Xiao Zhu, Zhiping Lai, Bingcan Chen, and Zhongyu Yang*. “A General Ca-MOF Platform with Enhanced Acid/Base Stability for Enzyme Encapsulation and Biocatalysis”. Chem catalysis 2021, 1, 146.
20. Qiaobin Li, Yanxiong Pan*, Hui Li, Linda Alhalhooly, Yue Li, Yongki Choi, Bingcan Chen*, Zhongyu Yang*, “Size-tunable Metal-Organic Framework Coated Magnetic Nanoparticles for Enzyme Encapsulation and Large-Substrate Biocatalysis”. ACS Appl. Mater. Interfaces 2020, 12, 41794.
19. Jasmin Farmakes, Isabelle Schuster, Amanda Overby, Lina Alhalhooly, Mary Lenertz, Qiaobin Li, Angel Ugrinov, Yongki Choi, Yanxiong Pan*, Zhongyu Yang*. “Enzyme Immobilization on Graphite Oxide (GO) Surface via One-pot Synthesis of GO/Metal-Organic Framework Composites for Large-Substrate Biocatalysis”. ACS Appl. Mater. Interfaces 2020, 12, 23119.
18. Yanxiong Pan#, Oksana Zholobko#, Hui Li, Jing Jin, Jinlian Hu, Bingcan Chen, Andriy Voronov*, Zhongyu Yang*. “Spatial Distribution and Solvent Polarity-Triggered Release of Polypeptide Incorporated into Invertible Micellar Assemblies”. ACS Appl. Mater. Interfaces 2020, 12, 12075.
17. Qi Sun#, Yanxiong Pan#, Xiaoliang Wang, Hui Li, Jasmin Farmakes, Briana Aguila, Zhongyu Yang, Shengqian Ma*. “Mapping out the Degree of freedom of Hosted Enzymes in Confined Spatial Environments”. Chem 2019, 5, 3184.
16. Hui Li#, Yanxiong Pan#, Jasmin Farmakes, Feng Xiao, Guodong Liu, Bingcan Chen, Xiao Zhu, Jiajia Rao, Zhongyu Yang*. “A Sulfonated Mesoporous Silica Nanoparticle for Enzyme Protection against Denaturants and Controlled Release under Reducing Conditions”. J. Colloid. Inter. Sci. 2019, 556, 292.
15. Sunanda Neupane, Kristen Patnode, Hui Li, Kwaku Baryeh, Guodong Liu, Jinlian Hu, Bingcan Chen, Yanxiong Pan*, Zhongyu Yang*. “Enhancing Enzyme Immobilization on Carbon Nanotubes (CNTs) via Metal-Organic Frameworks (MOFs) for Large Substrate Biocatalysis”. ACS Appl. Mater. Interfaces 2019, 11, 12133.
14. Yanxiong Pan, Jinlian Hu*, Zhongyu Yang, Lin Tang. “From Fragile Plastic to Room-Temperature Self-healing Elastomer though Tuning Quadruple Hydrogen Bonding Interaction Motif”. ACS Appl. Polym. Mater. 2019, 1, 425.
13. Yanxiong Pan, Hui Li, Jasmin Farmakes, Feng Xiao, Bingcan Chen, Shengqian Ma*, Zhongyu Yang*. “How do Enzymes Orient when Trapped on Metal-Organic Framework (MOF) Surfaces?”. J. Am. Chem. Soc. 2018, 140, 16032.
12. Yanxiong Pan#, Oksana Zholobko#, Andriy Voronov, Zhongyu Yang*. “Inversion of Polymeric Micelles Probed by Spin Labeled Peptide Incorporation and Electron Paramagnetic Resonance”. J. Phys. Chem. C, 2018, 122, 25692.
11. Yanxiong Pan, Bingrui Li, Zhi Liu, Zhongyu Yang, Xu Yang, Kai Shi, Wei Li, Chao Peng, Weicai Wang, Xiangling Ji*. “Superfast and Reversible Thermo-Response of Poly(N-isopropylacrylamide) Hydrogels Grafted on Macroporous Polyvinyl Alcohol Formaldehyde Sponge”. ACS Appl. Mater. Interfaces 2018, 10, 32747.
10. Sunanda Neupane#, Yanxiong Pan#, Hui Li, Kristen Patnode, Jasmin Farmakes, Guodong Liu, Zhongyu Yang*. “Engineering Protein-Gold Nanoparticle/Nanorod Complexation via Surface Modification for Protein Immobilization and Potential Therapeutic Applications”. ACS Appl. Nano Mater. 2018, 1, 4053.
9. Yanxiong Pan, Sunanda Neupane, Jasmin Farmakes, Myungkeun Oh, Kylie Bentz, Yongki Choi, Zhongyu Yang*. “Insights on the Structure, Molecular Weight and Activity of an Antibacterial Protein–Polymer Hybrid”. ChemPhysChem. 2018, 19, 651.
8. Sunanda Neupane#, Yanxiong Pan#, Sunitha Takalkar, Kylie Bentz, Jasmin Farmakes, Yi Xu, Bingcan Chen, Guodong Liu, Steven Y Qian, Zhongyu Yang*. “Probing the Aggregation Mechanism of Gold Nanoparticles Triggered by a Globular Protein”. J. Phys. Chem. C 2017, 121, 1377.
7. Yanxiong Pan*, Sunanda Neupane, Jasmin Farmakes, Bingqing Liu, Wenfang Sun, Zhongyu Yang*. “Spin-Labeling of Polymeric Micelles and Application in Probing Micelle Swelling Using EPR Spectroscopy”. J. Polym. Sci., Part B: Polym. Phys. 2017, 55, 1770.
6. Yanxiong Pan#, Sunanda Neupane, Jasmin Farmakes, Michael Bridges, James Froberg, Jiajia Rao, Steven Y. Qian, Guodong Liu, Yongki Choi, and Zhongyu Yang*. “Probing the Structural Basis and Adsorption Mechanism of an Enzyme on Nano-sized Protein Carriers.” Nanoscale 2017, 9, 3512.
5. Yanxiong Pan, Kai Shi, Chao Peng, Weicai Wang, Yunxia Luo, Xiangling Ji*. “Highly efficient macroporous adsorbents for toxic metal ions in water systems based on polyvinyl alcohol–formaldehyde sponges”. J. Mater. Chem. A. 2016, 4, 2537.
4. Yanxiong Pan, Kai Shi, Zhi Liu, Weicai Wang, Chao Peng, Xiangling Ji*. “Synthesis of a New Kind of Macroporous Polyvinyl-Alcohol Formaldehyde Based Sponge and Its Water Superabsorption Performance”. RSC Adv. 2015, 5, 78780.
3. Yanxiong Pan, Chao Peng, Kai Shi, Weicai Wang, Zhi Liu, Xiangling Ji*. “Evaluation of Hydrophobic Polyvinyl Alcohol Formaldehyde Sponge as a Absorbent for Oil Spill”. ACS Appl. Mater. Interfaces 2014, 6, 8651.
2. Yanxiong Pan, Chao Peng, Kai Shi, Weicai Wang, Zhi Liu, Xiangling Ji*. “Preparation and Absorption Behavior to Organic Pollutants of Macroporous Hydrophobic Polyvinyl Alcohol-Formaldehyde Sponges”. RSC Adv. 2014, 4, 35620.
1. Yanxiong Pan, Weicai Wang, Chao Peng, Kai Shi, Yunxia Luo, Xiangling Ji*. “Novel Hydrophobic Polyvinyl Alcohol-Formaldehyde Foams for Organic Solvents Absorption and Effective Separation”. RSC Adv. 2014, 4, 660.
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书籍章节
1 Yanxiong Pan, Hui Li, Qiaobin Li, Mary Lenertz, Drew Jordahl, Zhongyu Yang. “.Electron Paramagnetic Resonance (EPR) spectroscopy on polymeric materials: understanding the lifetime and sustainability of polymers”. Encyclopedia of Polymers, Polymeric Materials, and Polymer Technology

成果评述

从不同维度来探究大分子（包括生物大分子和合成高分子）结构与性能/功能之间的关系，取得的创新性成果如下：（1）结合电子顺磁共振（EPR）波谱和位置定点自旋标记（SDSL）技术探明受限于复杂的纳米尺度材料表面及孔道内部的生物大分子运动及取向信息与生物催化活性的关系；（2）采用EPR跟踪SDSL生物大分子和合成高分子的动力学，揭示其结构演化过程；（3）调控多孔高分子材料网络结构和孔壁表面的组成得到亲疏水可调的聚乙烯醇基多孔材料，赋予材料优异的宏观吸收/吸附/响应性能。截止目前，申请人以通讯/第一作者发表SCI论文总计30篇，以第一发明人获授权中国发明专利5项。
近五年来，以通讯/第一作者发表论文24篇，包括J. Am. Chem. Soc.（1篇）、Chem（1篇）、Chem Catalysis（2篇）、Cell Rep. Phys. Sci.（1篇）、Green Chem.（1篇）、ACS Appl. Mater. Interfaces（9篇）、Nanoscale（2篇）等，并应邀撰写书籍一章。

研究组人员概况

所在课题组为高分子物理与化学国家重点实验室姬相玲研究员课题组

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潘艳雄 研究员

潘艳雄　研究员