学术报告
高分子科学系列讲座134讲：Prof. Gregory N. Tew, Chemically Rich Macromolecules: From Proteins Mimics to Advanced Materials
文章来源： 发布时间：2012-06-04
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报告题目：Chemically Rich Macromolecules: From Proteins Mimics to Advanced Materials（No. PSLAB134-PS2012-12） |
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报 告 人：Prof. Gregory N. Tew |
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单 位：PSE, UMASS |
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报告时间：2012年6月6日（星期三 ）上午10:00 |
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报告地点：主楼四楼学术厅（410房间) |
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报告内容摘要：
Our primary research aim is to create new materials using a combination of principles, many of which are inspired by biology. In addition, the design of simple molecules that mimic the complex structures and functions of biology is at the heart of our work. In this presentation, we will illustrate several examples of these principles including facially amphiphilic polymers which serve as novel antimicrobial peptide mimics, polymers designed to access the interior of cells, new hydrogels with robust mechanical properties, and unique metal-ligand containing polymers. For example, we present the first metal cation-based anion exchange membranes (AEMs), synthesized by copolymerization and cross-linking of a norbornene monomer functionalized with a water-soluble bis(terpyridine)ruthenium(II) complex and dicyclopentadiene. Each ruthenium complex has two associated counter anions, unlike most ammonium- and phosphonium-based membranes with single cation-anion pairs. In another example, we learn to program synthetic polymers and oligomers with the appropriate chemical information that adequately capture the biological activity of proteins. The synthetic approach easily allows doubling the density of guanidine functional groups, which increases the transduction efficiency of the sequences. Cellular uptake studies on three different cell lines (HEK 293T, CHO, and Jurkat T cells) confirm that these synthetic analogs are highly efficient novel protein transduction domain mimics (PTDMs), that are more effective than TAT49-57 and nonaarginine (R9) and also highlights the usefulness of polymer chemistry at the chemistry- biology interface. |
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Prof. Gregory N. Tew |
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Education: University of Pennsylvania, The Medical School 2000-2001 Post-doctoral Fellow Research Advisor: Prof. William F. DeGrado University of Illinois at Urbana-Champaign 1995-2000 Ph.D., Materials Chemistry Research Advisor: Prof. Samuel I. Stupp North Carolina State University 1989-1995 B.S., Chemistry, Magna Cum Laude Research Advisor: Prof. David A. Shultz Professional Positions: University of Massachusetts-Amherst 2011-2012 Professor, Polymer Science & Engineering University of Massachusetts – Amherst 2011-2012 Adjunct Professor, Molecular & Cellular Biology University of Massachusetts – Amherst 2007 Associate Professor, Polymer Science and Engineering University of Massachusetts – Amherst 2001-2007 Assistant Professor, Polymer Science and Engineering |
